During birth, a calf begins an abundance of physiologic adjustments necessary for
extra-uterine life. Proper physiologic adjustments are necessary for the health of
the calf and influence values for pharmacokinetic and pharmacodynamic variables used
to calculate a rational dosage regimen for the calf. General concepts of neonatal
clinical pharmacology have been reviewed [
1
,
2
]. Many articles have been published that describe the pharmacokinetics of specific
drugs in calves, but few articles report results of well-designed clinical investigations
of treatments of naturally occurring diseases to confirm application of those data.To read this article in full you will need to make a payment
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References
- Pharmacology in neonatal calves. Proceedings of the American Association of Bovine Practitioners.The Bovine Proceedings. 1992; 24: 96-100
- Clinical pharmacology of antimicrobial drugs for the treatment of septic neonatal calves.Vet Clin North Am Food Anim Pract. 1991; 7: 695-711
- Cold thermoregulation in the newborn calf.Vet Clin North Am Food Anim Pract. 1994; 10: 69-105
- The effect of E. coli endotoxin induced fever on the blood levels of antimicrobial drugs after intravenous and intramuscular administration in veal calves.in: van Miert A.S.J.P.A.M. Frens J. van der Kreek F.W. Trends in veterinary pharmacology and toxicology. Elsevier Scientific Publishing Co, Amsterdam1980: 77-86
- Fever and reticulo-ruminal dysfunction.in: van Miert A.S.J.P.A.M. Frens J. van der Kreek F.W. Trends in veterinary pharmacology and toxicology. Elsevier Scientific Publishing Co, Amsterdam1980: 184-192
- Some biopharmaceutical considerations of subcutaneous and intramuscular injections used in veterinary medicine.in: van Miert A.S.J.P.A.M. Frens J. van der Kreek F.W. Trends in veterinary pharmacology and toxicology. Elsevier Scientific Publishing Co, Amsterdam1980: 47-53
- Injection sites and drug bioavailability.in: van Miert A.S.J.P.A.M. Frens J. van der Kreek F.W. Trends in veterinary pharmacology and toxicology. Elsevier Scientific Publishing Co, Amsterdam1980: 54-60
- Effect of injection site on bioavailability of aminopenicillins in calves.in: van Miert A.S.J.P.A.M. Frens J. van der Kreek F.W. Trends in veterinary pharmacology and toxicology. Elsevier Scientific Publishing Co, Amsterdam1980: 337-338
- The effect of animal health products on the formation of injection site lesions in subprimals of experimentally injected beef calves.Can Vet J. 2000; 41: 617-622
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© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
