Review Article| Volume 39, ISSUE 1, P73-91, March 2023

The Role of Histopathology in Ruminant Diagnostics


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.


      Subscribe to Veterinary Clinics: Food Animal Practice
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Steicke M.
        • Yang G.
        • Dinh T.N.
        • et al.
        The penetration of methanol into bovine cardiac and hepatic tissues is faster than ethanol and formalin.
        Eur J Histochem. 2018; 62: 2880
      1. Robbins and cotran pathologic basis of disease. Tenth ed. Elsevier Saunders, Philadelphia2021
      2. Pathologic basis of veterinary disease. 6th ed. Elsevier, St. louis, MO2017
        • Ensley S.
        Ionophore use and toxicosis in cattle.
        Vet Clin North Am Food Anim Pract. 2020; 36: 641-652
        • Booker C.W.
        • Abutarbush S.M.
        • Morley P.S.
        • et al.
        Microbiological and histopathological findings in cases of fatal bovine respiratory disease of feedlot cattle in Western Canada.
        Can Vet J. 2008; 49: 473-481
        • Uribe J.A.
        • Coura F.
        • Nunes P.
        • et al.
        Septicemic salmonellosis in pre weaned calves caused by Salmonella dublin.
        Res J Vet Pract. 2015; 3: 69-75
        • Loy J.D.
        • Leger L.
        • Workman A.M.
        • et al.
        Development of a multiplex real-time PCR assay using two thermocycling platforms for detection of major bacterial pathogens associated with bovine respiratory disease complex from clinical samples.
        J Vet Diagn Invest. 2018; 30: 837-847
        • Thonur L.
        • Maley M.
        • Gilray J.
        • et al.
        One-step multiplex real time RT-PCR for the detection of bovine respiratory syncytial virus, bovine herpesvirus 1 and bovine parainfluenza virus 3.
        BMC Vet Res. 2012; 8: 37
        • Woolums A.R.
        Feedlot acute interstitial pneumonia.
        Vet Clin North Am Food Anim Pract. 2015; 31: 381-389
        • Blood D.
        Atypical interstitial pneumonia of cattle.
        Can Vet J. 1962; 2: 40-47
        • Doster A.R.
        Bovine atypical interstitial pneumonia.
        Vet Clin North Am Food Anim Pract. 2010; 26: 395-407
        • Galitzer S.J.
        • Kruckenberg S.M.
        • Kidd J.R.
        Pathologic changes associated with experimental lasalocid and monensin toxicosis in cattle.
        Am J Vet Res. 1986; 47: 2624-2626
        • Hudson L.M.
        • Kerr L.A.
        • Maslin W.R.
        Gossypol toxicosis in a herd of beef calves.
        J Am Vet Med Assoc. 1988; 192: 1303-1305
        • Barth A.T.
        • Kommers G.D.
        • Salles M.S.
        • et al.
        Coffee senna (senna occidentalis) poisoning in cattle in Brazil.
        Vet Hum Toxicol. 1994; 36: 541-545
        • Calò M.
        • Lo Cascio P.
        • Licata P.
        • et al.
        Effects of monensin on Na+/K(+)-ATPase and Ca(++)-AtPase activities in chick skeletal muscle and myocardium after subacute treatment.
        Eur J Histochem. 2002; 46: 309-315
        • O'Toole D.
        • Sondgeroth K.S.
        Histophilosis as a natural disease.
        Curr Top Microbiol Immunol. 2016; 396: 15-48
        • Welsh R.D.
        • Dye L.B.
        • Payton M.E.
        • et al.
        Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994--2002.
        J Vet Diagn Invest. 2004; 16: 426-431
        • Margineda C.A.
        • O’Toole D.
        • Prieto M.
        • et al.
        Histophilus somni myocarditis and leptomeningitis in feedlot cattle: case report and occurrence in South America.
        J Vet Diagn Invest. 2019; 31: 893-898
        • Headley S.A.
        • Voltarelli D.
        • de Oliveira V.H.
        • et al.
        Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil.
        Trop Anim Health Prod. 2015; 47: 403-413
        • Madampage C.A.
        • Rawlyk N.
        • Crockford G.
        • et al.
        Single nucleotide polymorphisms in the bovine Histophilus somni genome; a comparison of new and old isolates.
        Can J Vet Res. 2015; 79: 190-200
        • Capik S.F.
        • Moberly H.K.
        • Larson R.L.
        Systematic review of vaccine efficacy against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in North American cattle.
        Bovine Pract. 2021; 55: 125-133
        • Griffin D.
        Field necropsy of cattle and diagnostic sample submission.
        Vet Clin North Am Food Anim Pract. 2012; 28: 391-405
        • Rech R.
        • Giaretta P.R.
        • Brown C.
        • et al.
        Gross and histopathological pitfalls found in the examination of 3,338 cattle brains submitted to the BSE surveillance program in Brazil.
        Pesquisa Veterinaria Brasileira. 2018; 38: 2099-2108
        • Maxie M.G.
        Jubb, Kennedy, and Palmer’s pathology of domestic animals. 6th. Elsevier, Amsterdam, Netherlands2016
        • Matto C.
        • Varela G.
        • Mota M.
        • et al.
        Rhombencephalitis caused by Listeria monocytogenes in a pastured bull.
        J Vet Diagn Invest. 2017; 29 (104063871668911)
        • Vandevelde M.
        • Higgins R.J.
        • Overmann A.
        Veterinary neuropathology : essentials of theory and practice.
        Wiley-Blackwell, Oxford2012
        • Sreekanth C.
        • Shakuntala Rao N.
        • Manivannan K.
        • et al.
        Caecum and appendix in ruminants and man: a comparative study.
        J Evol Med Dental Sci. 2014; 3: 8033-8039
        • Stockdale P.H.
        The pathogenesis of the lesions produced by Eimeria zuernii in calves.
        Can J Comp Med. 1977; 41: 338-344
        • Boileau M.J.
        • Kapil S.
        Bovine coronavirus associated syndromes.
        Vet Clin North Am Food Anim Pract. 2010; 26: 123-146
        • Pearson G.R.
        • Logan E.F.
        The rate of development of postmortem artefact in the small intestine of neonatal calves.
        Br J Exp Pathol. 1978; 59: 178-182
        • Goossens E.
        • Valgaeren B.R.
        • Pardon B.
        • et al.
        Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases: a review on bovine necro-haemorrhagic enteritis.
        Vet Res. 2017; 48: 9
        • Simpson K.M.
        • Callan R.J.
        • Van Metre D.C.
        Clostridial abomasitis and enteritis in ruminants.
        Vet Clin North Am Food Anim Pract. 2018; 34: 155-184
        • Clothier K.
        • Anderson M.
        Evaluation of bovine abortion cases and tissue suitability for identification of infectious agents in California diagnostic laboratory cases from 2007 to 2012.
        Theriogenology. 2016; 85: 933-938
        • Kirkbride C.A.
        Etiologic agents detected in a 10-year study of bovine abortions and stillbirths.
        J Vet Diagn Invest. 1992; 4: 175-180
        • Botta C.
        • Pellegrini G.
        • Hässig M.
        • et al.
        Bovine fetal placenta during pregnancy and the postpartum period.
        Vet Pathol. 2019; 56: 248-258
        • Holler L.D.
        Ruminant abortion diagnostics.
        Vet Clin North Am Food Anim Pract. 2012; 28: 407-418